期刊论文

Chen, Shi;Lee, Sang Yup

英文

Proceedings of the National Academy of Sciences of the United States of America

0027-8424

2018

115

13

E2988-E2996

10.1073/pnas.1721916115

ACKNOWLEDGMENTS. We thank Yizhou Zhang for preparing Fig. 4 and Yuquan Xu and Ping Xu for providing the vectors. This work was supported by grants from the National Science Foundation of China (Grants 31720103906 and 31520103902), the 973 program of the Ministry of Science and Technology (Grant 2013CB734003), and the Young One Thousand Talent program of China. The work of S.Y.L. was further supported by the Systems Metabolic Engineering for Biorefineries Program (Grants NRF-2012M1A2A2026556 and NRF-2012M1A2A2026557) from the Ministry of Science and Information and Communications Technology through the National Research Foundation of Korea.

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The chemical diversity of physiological DNA modifications has expanded with the identification of phosphorothioate (PT) modification in which the nonbridging oxygen in the sugarphosphate backbone of DNA is replaced by sulfur. Together with DndFGH as cognate restriction enzymes, DNA PT modification, which is catalyzed by the DndABCDE proteins, functions as a bacterial restriction-modification (R-M) system that protects cells against invading foreign DNA. However, the occurrence of dnd systems across a large number of bacterial genomes and their ...