Photoelectrochemical aptasensing and fluorescence imaging co-joint detecting MCF-7 cells in whole blood via an inertial separation microfluidic chip

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成果类型：

期刊论文

作者：

He, Jiangling;Xu, Xingxing;Zhang, Yi;Jiang, Shangjun;Lin, Qingfeng;...

通讯作者：

Li, CY;Deng, HP

作者机构：

[He, Jiangling] Wuhan Polytech Univ, Natl R&D Ctr Se rich Agr Prod Proc, Hubei Engn Res Ctr Deep Proc Green Se Rich Agr Pro, Sch Modern Ind Selenium Sci & Engn, Wuhan 430023, Peoples R China.

[Wang, Yanying; Jiang, Shangjun; Xu, Xingxing; Li, Chunya; Zhang, Yi; Zhang, Huijuan; Li, CY; Lin, Qingfeng] South Cent Minzu Univ, Sch Chem & Mat Sci, Key Lab Catalysis & Energy Mat Chem,Minist Educ, Wuhan 430074, Peoples R China.

[Wang, Yanying; Jiang, Shangjun; Xu, Xingxing; Li, Chunya; Zhang, Yi; Zhang, Huijuan; Li, CY; Lin, Qingfeng] South Cent Minzu Univ, Sch Chem & Mat Sci, Key Lab Analyt Chem State Ethn Affairs Commiss, Wuhan 430074, Peoples R China.

[Deng, Hongping] Wuhan Univ, Dept Vasc Surg, Renmin Hosp, Wuhan 430060, Peoples R China.

[Xiong, Xiaoxing] Wuhan Univ, Dept Neurosurg, Renmin Hosp, Wuhan 430060, Peoples R China.

通讯机构：

[Deng, HP ] W

[Li, CY ] S

South Cent Minzu Univ, Sch Chem & Mat Sci, Key Lab Catalysis & Energy Mat Chem,Minist Educ, Wuhan 430074, Peoples R China.

South Cent Minzu Univ, Sch Chem & Mat Sci, Key Lab Analyt Chem State Ethn Affairs Commiss, Wuhan 430074, Peoples R China.

Wuhan Univ, Dept Vasc Surg, Renmin Hosp, Wuhan 430060, Peoples R China.

语种：

英文

关键词：

Circulating tumor cells;Dual-model detection;Fluorescence imaging;Microfluidic chip;Photoelectrochemical sensing

期刊：

Talanta

ISSN：

0039-9140

年：

2025

卷：

286

页码：

127488

DOI：

10.1016/j.talanta.2024.127488

基金类别：

CRediT authorship contribution statement Jiangling He: Writing – review & editing, Writing – original draft, Visualization, Software, Methodology, Formal analysis, Conceptualization. Xingxing Xu: Writing – original draft, Visualization, Software, Methodology, Formal analysis, Data curation. Yi Zhang: Software, Formal analysis. Shangjun Jiang: Software, Formal analysis. Qingfeng Lin: Software. Huijuan Zhang: Writing – review & editing. Xiaoxing Xiong: Validation. Yanying Wang: Writing – review & editing, acquisition, Acknowledgments This work has been financially supported by the National Natural Science Foundation of China (No. 22074160 , 21874157 , 21675175 ); The Fund for Scientific Research Platforms of South-Central Minzu University (No. PTZ24010 ); The Fund for Academic Innovation Teams of South-Central Minzu University (No. XTZ24010 ); The Open Project of Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University (No. KLSAOFM2305 ).

机构署名：

本校为第一机构

院系归属：

硒科学与工程现代产业学院

摘要：

The mortality rate of tumor is still very high till now. Circulating tumor cells (CTCs) are the major culprit of high cancer mortality. To improve survival rate of cancer patients, real-time monitoring and quantitative detection of CTCs are of indescribable value. However, due to the extremely small content and heterogeneous characteristics of CTCs, to accurately detect CTCs is still a tremendous challenge in clinical trials. Herein, the photoelectrochemical aptasensing and fluorescence imaging were co-joint to detect MCF-7 cells in whole blood...

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Photoelectrochemical aptasensing and fluorescence imaging co-joint detecting MCF-7 cells in whole blood via an inertial separation microfluidic chip

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