Transgenerational inheritance of ovarian development deficiency induced by maternal diethylhexyl phthalate exposure

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成果类型：

期刊论文

作者：

Zhang, Xi-Feng;Zhang, Teng;Han, Zhe;Liu, Jing-Cai;Liu, Yu-Ping;...

通讯作者：

Shen, Wei

作者机构：

[Liu, Jing-Cai; Ma, Jun-Yu; Zhang, Teng; Shen, Wei; Li, Lan; Zhang, Xi-Feng] Qingdao Agr Univ, Coll Anim Sci & Technol, Key Lab Anim Reprod & Germplasm Enhancement Univ, Qingdao 266109, Peoples R China.

[Han, Zhe; Zhang, Xi-Feng] Wuhan Polytech Univ, Coll Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.

[Liu, Jing-Cai] Qingdao Agr Univ, Coll Life Sci, Qingdao 266109, Peoples R China.

[Liu, Yu-Ping] Qingdao Agr Univ, Hosp Sch, Qingdao 266109, Peoples R China.

通讯机构：

[Shen, Wei] Q

Qingdao Agr Univ, Coll Anim Sci & Technol, Key Lab Anim Reprod & Germplasm Enhancement Univ, Qingdao 266109, Peoples R China.

语种：

英文

关键词：

DEHP;follicle;meiosis;oocyte;premature oocyte failure

期刊：

Reproduction, Fertility and Development

ISSN：

1031-3613

年：

2015

卷：

期：

页码：

1213-1221

DOI：

10.1071/RD14113

基金类别：

National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31201120]; Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-12-1026]; Foundation of Distinguished Young ScholarsNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [JQ201109]; Nature Science Foundation [ZR2013CQ029]; Foundation of Education Department of Shandong Province [J11LC20]; Yantai Hi-Tech Zone Blue Ocean Talent Plan

机构署名：

本校为其他机构

院系归属：

生命科学与技术学院

摘要：

Diethylhexyl phthalate (DEHP) is a widely used industrial additive for increasing plastic flexibility. It disrupts the physiological functions of endogenous hormones and induces abnormal development of mammals. The objectives of the present study were to evaluate the effects of DEHP exposure on ovarian development of pregnant mice and whether the effects are inheritable. We found that the synthesis of oestradiol in pregnant mice after DEHP exposure was significantly decreased, and that the first meiotic progression of female fetal germ cells was delayed. Furthermore, the DNA methylation level ...

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Transgenerational inheritance of ovarian development deficiency induced by maternal diethylhexyl phthalate exposure

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