Mitochondrial pathway is involved in the protective effects of alpha-ketoglutarate on hydrogen peroxide induced damage to intestinal cells

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成果类型：

期刊论文

作者：

Jiang, Qian;Liu, Gang;Wang, Xiuqi;Hou, Yongqing;Duan, Yehui;...

通讯作者：

Yao, Kang

作者机构：

[Liu, Gang; Yao, Kang; Duan, Yehui; Wu, Guoyao; Yin, Yulong; Jiang, Qian] Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Hunan, Peoples R China.

[Liu, Gang; Yao, Kang; Duan, Yehui; Wu, Guoyao; Yin, Yulong; Jiang, Qian] Hunan Prov Engn Res Ctr Hlth Livestock & Poultry, Changsha 410125, Hunan, Peoples R China.

[Liu, Gang; Yao, Kang; Duan, Yehui; Wu, Guoyao; Yin, Yulong; Jiang, Qian] Minist Agr, Sci Observing & Expt Stn Anim Nutr & Feed Sci Sou, Changsha 410125, Hunan, Peoples R China.

[Duan, Yehui; Jiang, Qian] Univ Chinese Acad Sci, Beijing 100039, Peoples R China.

[Liu, Gang; Yao, Kang; Yin, Yulong] Hunan Collaborat Innovat Ctr Utilizat Bot Funct I, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Yao, Kang] C

[Yao, Kang] H

[Yao, Kang] M

Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Hunan, Peoples R China.

Hunan Prov Engn Res Ctr Hlth Livestock & Poultry, Changsha 410125, Hunan, Peoples R China.

语种：

英文

关键词：

alpha-ketoglutarate;cell apoptosis;intestinal porcine epithelial cells;mitochondrial respiration;oxidative damage

期刊：

Oncotarget

ISSN：

1949-2553

年：

2017

卷：

期：

页码：

74820-74835

DOI：

10.18632/oncotarget.20426

基金类别：

National Science Foundation for Distinguished Young Scholars of Hunan ProvinceNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [2016JJ1015]; Key Programs of frontier scientific research of the Chinese Academy of Sciences; National Basic Research Program of ChinaNational Basic Research Program of China [2013CB127306]; Open Foundation of Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences [ISA2016101]; Chinese Academy of Sciences "Hundred Talent" award; National Natural Science Foundation ProjectNational Natural Science Foundation of China (NSFC) [31472107]

机构署名：

本校为其他机构

院系归属：

动物科学与营养工程学院

摘要：

Alpha-ketoglutarate, a key intermediate in the Krebs cycle, has been reported to benefit intestinal health. We tested whether alpha-ketoglutarate can protect intestinal cells against hydrogen peroxide induced damage and aimed to reveal the underlying mechanism. Intestinal porcine epithelial cell line J2 were cultured in Dulbecco's Modified Eagle Medium-High glucose with or without alpha-ketoglutarate and hydrogen peroxide. Cell viability, proliferation, mitochondrial respiration, mitochondrial membrane potential, antioxidant function, apoptosis...

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Mitochondrial pathway is involved in the protective effects of alpha-ketoglutarate on hydrogen peroxide induced damage to intestinal cells

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