Palmitoylation couples insulin hypersecretion with β cell failure in diabetes

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成果类型：

期刊论文

作者：

Dong, Guifang;Adak, Sangeeta;Spyropoulos, George;Zhang, Qiang;Feng, Chu;...

通讯作者：

Wei, Xiaochao;Semenkovich, CF

作者机构：

[Zhang, Qiang; Kitamura, Rie Asada; Wei, Xiaochao; Semenkovich, Clay F.; Dong, Guifang; Remedi, Maria S.; Adak, Sangeeta; Yin, Li; Shyr, Zeenat; Morikawa, Shuntaro; Speck, Sarah L.; Urano, Fumihiko; Feng, Chu] Washington Univ, Div Endocrinol Metab & Lipid Res, St Louis, MO 63110 USA.

[Dong, Guifang] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

[Spyropoulos, George] Washington Univ, Dept Pediat, St. Louis, MO 63110 USA.

[Dickinson, Bryan C.; Kathayat, Rahul S.] Univ Chicago, Dept Chem, Chicago, IL 60637 USA.

[Semenkovich, Clay F.; Remedi, Maria S.; Ng, Xue Wen; Piston, David W.] Washington Univ, Dept Cell Biol & Physiol, St. Louis, MO 63110 USA.

通讯机构：

[Wei, XC; Semenkovich, CF ] W

Washington Univ, Div Endocrinol Metab & Lipid Res, St Louis, MO 63110 USA.

Washington Univ, Dept Cell Biol & Physiol, St. Louis, MO 63110 USA.

语种：

英文

关键词：

S-acylation;acyl-protein thioesterases;beta cell failure;lipotoxicity;type 2 diabetes

期刊：

Cell Metabolism

ISSN：

1550-4131

年：

2023

卷：

期：

页码：

332-344.e7

DOI：

10.1016/j.cmet.2022.12.012

基金类别：

Washington University Centene Personalized Medicine Initiative [P19-00559]; Washington University Diabetes Research Center [DK020579]; NIH [DK101392, DK056341, DK115972, DK123301, DK112921, GM119840, T32 HL125241, F30 DK131830, HL157154]; China Scholarship Council (CSC) [201608420067]; Manpei Suzuki Diabetes Foundation Fellowship; JSPS Overseas Research Fellowship

机构署名：

本校为其他机构

院系归属：

动物科学与营养工程学院

摘要：

Hyperinsulinemia often precedes type 2 diabetes. Palmitoylation, implicated in exocytosis, is reversed by acyl-protein thioesterase 1 (APT1). APT1 biology was altered in pancreatic islets from humans with type 2 diabetes, and APT1 knockdown in nondiabetic islets caused insulin hypersecretion. APT1 knockout mice had islet autonomous increased glucose-stimulated insulin secretion that was associated with prolonged insulin granule fusion. Using palmitoylation proteomics, we identified Scamp1 as an APT1 substrate that localized to insulin secretory...

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Palmitoylation couples insulin hypersecretion with β cell failure in diabetes

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