The signatures of liver metabolomics and gut microbiota in high-fat diet fed mice supplemented with rhododendrol

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成果类型：

期刊论文

作者：

Li, Xiaoping;Wang, Yu;Yu, Chengwei;Yao, Yexuan;Chen, Xi;...

通讯作者：

Yao, Zhao(yaozhao666@126.com);Luo, Ting(ting.luo@ncu.edu.cn)

作者机构：

[Deng, Ze-Yuan; Wang, Yu; Yao, Yexuan; Li, Xiaoping; Luo, Ting] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China.

[Yu, Chengwei] Jiangxi Normal Univ, Sch Hlth, Nanchang 330022, Jiangxi, Peoples R China.

[Chen, Xi] Wuhan Polytech Univ, Sch Food Sci & Engn, Wuhan 430023, Hubei, Peoples R China.

[Yao, Zhao] Jinggangshan Univ, Med Sch, Jian 343000, Jiangxi, Peoples R China.

通讯机构：

[Li, Xiaoping] S

[Yao, Zhao] M

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, 330047, China. ting.

Medical School of Jinggangshan University, Ji'an, Jiangxi, 343000, China.

语种：

英文

期刊：

FOOD & FUNCTION

ISSN：

2042-6496

年：

2022

卷：

期：

页码：

13052-13063

DOI：

10.1039/d2fo01214f

基金类别：

This work was financially supported by the National Natural Science Foundation of China (Grant No. 82160168), “Shuangqian Project” of Scientific and Technological Innovation of High-end Talents-Natural Science, Jiangxi Province (Grant No. jxsq2020101063), Natural Science Foundation of Jiangxi Province (Grant No. 20212BAB216075), and Central Government Guide Local Special Fund Project for Scientific and Technological Development of Jiangxi Province (Grant No. 20221ZDD02001).

机构署名：

本校为其他机构

院系归属：

食品科学与工程学院

摘要：

As aromatic compounds found within red fruits and berries, raspberry ketones (RK) have the potential for nonalcoholic fatty liver disease (NAFLD) amelioration. However, the mechanism of RK on NAFLD is unclear, and their bioactive metabolite is unknown. As the major metabolites of RK that are mainly distributed in the liver, rhododendrol (RHO) is used in our current study to test whether RHO accounts for the beneficial effect of RK on NAFLD and the underlying mechanism. In a 16-week trial, RHO significantly decreased final body weight, improved ...

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The signatures of liver metabolomics and gut microbiota in high-fat diet fed mice supplemented with rhododendrol

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