版权说明 操作指南
首页 > 成果 > 详情

Protective role of n6/n3 PUFA supplementation with varying DHA/EPA ratios against atherosclerosis in mice

认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Liu, Liang;Hu, Qinling;Wu, Huihui;Xue, Yihong;Cai, Liang;...
通讯作者:
Gong, Zhiyong
作者机构:
[Cai, Liang; Wu, Huihui; Gong, Zhiyong; Liu, Liang; Wu, Yongning; Hu, Qinling; Xue, Yihong; Fang, Min] Wuhan Polytech Univ, Coll Food Sci & Engn, 68 XueFuNan Rd, Wuhan 430023, Peoples R China.
[Cai, Liang; Wu, Huihui; Gong, Zhiyong; Liu, Liang; Wu, Yongning; Liu, Zhiguo; Hu, Qinling; Xue, Yihong; Fang, Min] Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Proc Agr Prod, Wuhan 430023, Peoples R China.
[Liu, Zhiguo] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.
[Yao, Ping] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Nutr & Food Hyg, Sch Publ Hlth, Wuhan 430030, Peoples R China.
通讯机构:
[Gong, Zhiyong] W
Wuhan Polytech Univ, Coll Food Sci & Engn, 68 XueFuNan Rd, Wuhan 430023, Peoples R China.
语种:
英文
关键词:
ABC transporter A1;ABC transporter G1;CD36 antigen;docosahexaenoic acid;fish oil;high density lipoprotein cholesterol;icosapentaenoic acid;linolenic acid;messenger RNA;oxidized low density lipoprotein receptor 1;perilla oil;polyunsaturated fatty acid;reactive oxygen metabolite;ABC transporter A1;ABC transporter G1;ABCA1 protein, mouse;ABCG1 protein, mouse;apolipoprotein E;cholesterol esterase;fish oil;linolenic acid;lysosomal acid lipase, mouse;omega 3 fatty acid;omega 6 fatty acid;perilla seed oil;scavenger receptor;sunflower oil;vegetable oil;animal experiment;animal model;Article;atherosclerotic plaque;body weight;controlled study;diet supplementation;female;gene expression;inflammation;lipid blood level;lipid diet;lipid metabolism;male;mouse;nonhuman;oxidative stress;protein blood level;protein expression;adverse effects;analysis;animal;aorta;atherosclerosis;C57BL mouse;chemistry;comparative study;dietary supplement;gene expression regulation;genetics;immunology;knockout mouse;metabolism;pathology;randomization;alpha-Linolenic Acid;Animals;Aorta;Apolipoproteins E;Atherosclerosis;ATP Binding Cassette Transporter 1;ATP Binding Cassette Transporter, Sub-Family G, Member 1;Diet, High-Fat;Dietary Supplements;Fatty Acids, Omega-3;Fatty Acids, Omega-6;Fish Oils;Gene Expression Regulation;Male;Mice, Inbred C57BL;Mice, Knockout;Plant Oils;Random Allocation;Receptors, Scavenger;Sterol Esterase
期刊:
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
ISSN:
0955-2863
年:
2016
卷:
32
页码:
171-180
基金类别:
This work was supported by the National High-tech Research and Development Projects ( 2010AA023003 ), National Natural Science Foundation of China (Nos. 31201351 and 31271855 ) and the Hubei Province Natural Science Foundation of China (No. 2013CFB481 ). We would like to thank Editage ( http://online.editage.cn /) for English language editing.
机构署名:
本校为第一且通讯机构
院系归属:
食品科学与工程学院
生命科学与技术学院
摘要:
The effects of n3 polyunsaturated fatty acids (PUFA) on cardiovascular disease are controversial. We currently explored the effects of various ratios of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on high-fat-induced atherosclerosis. In model apoE(-/-) mice, high-fat diets (HFD) were partially replaced with fish and algal oils (DHA/EPA 2:1, 1:1 and 1:2) and/or plant oils enriched in linoleic and alpha-linolenic acids with an n6/n3 ratio of 4:1. PUFA supplementation significantly reduced the atherosclerotic plaque area, serum lipid profile, inflammatory response, aortic ROS produ...

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com