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Molecular mechanism of the anti-gastric cancer activity of 1,2,3,6-tetra-O-galloyl-beta-D-glucose isolated from Trapa bispinosa Roxb. shell in vitro

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成果类型:
期刊论文
作者:
Wang, Limei;Yin, Dongjie;Fan, Yanhui;Min, Ting;Yi, Yang;...
通讯作者:
Hongxun Wang
作者机构:
[Wang, Hongxun; Fan, Yanhui; Wang, Limei; Yin, Dongjie] Wuhan Polytech Univ, Coll Life Sci & Technol, Wuhan, Peoples R China.
[Min, Ting; Yi, Yang] Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan, Peoples R China.
通讯机构:
[Hongxun Wang] A
Affiliation College of Life Science and Technology, Wuhan Polytechnic University, Wuhan, China
语种:
英文
关键词:
Apoptosis;Gastric cancer;Cancer treatment;Gene expression;Membrane potential;Mitochondrial membrane;Transcriptome analysis;PPAR signaling
期刊:
PLOS ONE
ISSN:
1932-6203
年:
2022
卷:
17
期:
6
页码:
e0269013
基金类别:
Primary Research & Developement Plan of Hubei Province [2020BBA046]
机构署名:
本校为第一机构
院系归属:
食品科学与工程学院
生命科学与技术学院
摘要:
Trapa bispinosa Roxb. is a traditional Chinese food which is well known for its medicinal properties. The shell of Trapa bispinosa has anticancer activity, maybe due to its high content of polyphenols. There are few studies on the chemical composition of Trapa bispinosa shells, then we isolated the active components from Trapa bispinosa shell and clarified the mechanism of its anticancer activity. One monomer compound was separated from the ethanol extract of the Trapa bispinosa shell by fractional extraction, silica gel, Sephadex LH-20 gel col...

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