期刊论文、会议论文

Yang, Wu;Yang, Xu

英文

Ferroelectrics

0015-0193

2019

546

1

1-12

Joint Symposium of the 9th International Conference of th Chinese-Society-of-Micro-Nano-Technology (CSMNT) / Microsystems and Nanoengineering Summit (MAN)

AUG 17-20, 2018

Hohhot, PEOPLES R CHINA

[Li, Yan;Wang, Pengcheng] Wuhan Polytech Univ, Key Lab Deep Proc Major Grain & Oil, Minist Educ, Coll Food Sci & Engn, Wuhan, Hubei, Peoples R China.^[Li, Jinquan;Yang, Xu] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Coll Life Sci, Wuhan, Hubei, Peoples R China.^[Wang, Yixin;Gong, Zhiyong;Yang, Wu] Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Coll Food Sci & Engn, Wuhan, Hubei, Peoples R China.

Chinese Soc Micro Nano Technol, China SocMat Res, Youth Work Comm, Tianjin Univ

2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND

TAYLOR & FRANCIS LTD

10.1080/00150193.2019.1592451

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21607117]

本校为第一且通讯机构

In this study, we performed a 3D organotypic culture of human lung fibroblast (HLF) in a microfluidic device. This 3D HLF model could partly simulate the biological responses of human lung. ɑ-MnO2 nanowires were successfully synthesized using the hydrothermal approach. Material characterization identified the existence of ɑ-MnO2 nanostructure. Based on this 3D organotypic HLF model, our results demonstrated that ɑ-MnO2 nanowires can induce cytotoxicity in dose-dependently. Because the accumulation of reactive oxygen species (ROS) and depleti...