期刊论文

Hou, Yongqing

英文

FRONTIERS IN BIOSCIENCE-LANDMARK

2768-6701

2011

16

1

1186-1196

10.2741/3783

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30871801]; Hubei Provincial Natural Science Foundation [2007ABC009]; USDA National Institute of Food and AgricultureUnited States Department of Agriculture (USDA) [2008-35206-18764]; Texas AgriLife Research [H-82000]; American Heart AssociationAmerican Heart Association [10GRNT4480020]; China Agricultural University

本校为第一且通讯机构

Alpha-ketoglutarate (AKG) is an intermediate of the Krebs cycle which bridges amino acid metabolism with glucose oxidation in animals. Of particular interest is the conversion of AKG into glutamate by mitochondrial glutamate dehydrogenase in the gastrointestinal tract where glutamate has multiple physiological functions (including regulation of cell function, neurotransmission, and gastric emptying). Additionally, AKG stimulates the initiation of catabolism of branched-chain amino acids (BCAA) via BCAA transaminase in enterocytes. Oxidation of AKG also provides large amounts of ATP and modulat...