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Design and construction of competitive, noncompetitive and uncompetitive nano inhibitors of enzymes

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成果类型:
期刊论文
作者:
Chen, Wen-Qi;Yu, Ying-Qi;Cao, Ling;Yin, Miao-Miao;Liu, Yi;...
通讯作者:
Jiang, Feng-Lei(fljiang@whu.edu.cn)
作者机构:
[Cao, Ling; Liu, Yi; Jiang, Feng-Lei; Yu, Ying-Qi; Chen, Wen-Qi] Wuhan Univ, Coll Chem & Mol Sci, Sauvage Ctr Mol Sci, Wuhan 430072, Peoples R China.
[Yin, Miao-Miao] Hubei Normal Univ, Coll Chem & Chem Engn, Hubei Key Lab Pollutant Anal & Reuse Technol, Huangshi 435002, Peoples R China.
[Liu, Yi] Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan 430023, Peoples R China.
通讯机构:
[Feng-Lei Jiang] S
Sauvage Center for Molecular Sciences, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China
语种:
英文
期刊:
Chemical Communications
ISSN:
1359-7345
年:
2022
卷:
58
期:
100
页码:
13911-13914
基金类别:
National Natural Science Foundation of China [21973071, 21773178, 21573168]; Natural Science Foundation of Tianjin [21JCQNJC01450, 21JCQNJC01470]; Science and Technology Plans of Tianjin [22ZYJDSS00070, 21ZYJDJC00050]
机构署名:
本校为其他机构
院系归属:
化学与环境工程学院
摘要:
Three common types of reversible inhibitors, namely competitive, noncompetitive and uncompetitive inhibitors, were designed and constructed by using enzymes with different surface charges and gold nanoparticles with different surface ligands and particle sizes. To our knowledge, it is the first time that an uncompeti...

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