GPX4 is a potential diagnostic and therapeutic biomarker associated with diffuse large B lymphoma cell proliferation and B cell immune infiltration

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成果类型：

期刊论文

作者：

Chen, Can;Li, Tongyu;Li, Yiwei;Chen, Zhenzhen;Shi, Pengfei;...

通讯作者：

Qian, SX;Li, Y

作者机构：

[Qian, Shenxian; Chen, Zhenzhen; Chen, Can; Shi, Pengfei; Li, Yiwei; Qian, SX] West Lake Univ, Hangzhou Peoples Hosp 1, Sch Med, Dept Hematol, Hangzhou 310006, Zhejiang, Peoples R China.

[Li, Tongyu] Ningbo First Hosp, Dept Hematol, Ningbo, Peoples R China.

[Li, Yun; Li, Yiwei] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Team Neonatal & Infant Dev Hlth & Nutr, NDHN, Wuhan, Peoples R China.

[Li, Yun] Kindstar Global Precis Med Inst, Wuhan, Peoples R China.

[Li, Yun] Wuhan Kindstar Med Lab Co Ltd, Dept Sci Res Project, Wuhan, Peoples R China.

通讯机构：

[Li, Y ; Qian, SX ] W

West Lake Univ, Hangzhou Peoples Hosp 1, Sch Med, Dept Hematol, Hangzhou 310006, Zhejiang, Peoples R China.

Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Team Neonatal & Infant Dev Hlth & Nutr, NDHN, Wuhan, Peoples R China.

语种：

英文

关键词：

DLBCL;GPX4;Single cells;B cell immune;Biomarker

期刊：

Heliyon

ISSN：

2405-8440

年：

2024

卷：

期：

页码：

e24857

DOI：

10.1016/j.heliyon.2024.e24857

基金类别：

Hangzhou science and technology Major Project [202004A15]; Hangzhou Medical health science and technology Major Project [Z20210039]; Zhejiang Province Traditional Chinese medicine science and technology project [2023ZR122]

机构署名：

本校为通讯机构

院系归属：

生命科学与技术学院

摘要：

At present, GPX4's role in the occurrence and development of diffuse large B lymphoma (DLBCL) is rarely reported. This study's purpose is to explore GPX4's significance in the diagnosis, treatment, and pathological mechanisms of DLBCL. The TIMER 2.0, GEPIA, and GEO databases were used to analyze GPX4's expression levels in DLBCL tissue, peripheral blood, and single cells, and evaluate its potential performance as a therapeutic and diagnostic marker. Cell experiments validate GPX4's role in DLBCL cells. And revealed the potential mechanism of GPX4's action from three aspects: immunity, pathogen...

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GPX4 is a potential diagnostic and therapeutic biomarker associated with diffuse large B lymphoma cell proliferation and B cell immune infiltration

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