Oppositely charged polysaccharide nanofibers coated gauze with hemostatic potential

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成果类型：

期刊论文

作者：

Wang, Ziying;Zheng, Xinwei;Chen, Qinhui*;Weng, Yunxiang;Sun, Xun;...

通讯作者：

Chen, Qinhui;Liu, Haiqing;Fang, Y;Sun, X;Fan, XM

作者机构：

[Wang, Ziying; Liu, Haiqing; Weng, Yunxiang; Fang, Yan; Zheng, Xinwei; Chen, Qinhui] Fujian Normal Univ, Coll Chem & Mat Sci, Fujian Prov Key Lab Polymer Mat, Fuzhou 350007, Fujian, Peoples R China.

[Sun, Xun] Xuzhou Vocat Coll Ind Technol, Coll Mat Engn, Xuzhou 221000, Peoples R China.

[Fan, Xianmou] Guangdong Med Univ, Affiliated Hosp, Dept Plast Surg, Zhanjiang 524000, Guangdong, Peoples R China.

[Wang, Guozhen] Wuhan Polytech Univ, Sch Food Sci & Engn, Wuhan 430023, Peoples R China.

通讯机构：

[Sun, X ] X

[Chen, QH; Fang, Y ; Liu, HQ] F

[Fan, XM ] G

Fujian Normal Univ, Coll Chem & Mat Sci, Fujian Prov Key Lab Polymer Mat, Fuzhou 350007, Fujian, Peoples R China.

Xuzhou Vocat Coll Ind Technol, Coll Mat Engn, Xuzhou 221000, Peoples R China.

语种：

英文

关键词：

Cotton gauze;Hemostasis;Polysaccharide

期刊：

International Journal of Biological Macromolecules

ISSN：

0141-8130

年：

2025

卷：

320

期：

Pt 4

页码：

146168

DOI：

10.1016/j.ijbiomac.2025.146168

基金类别：

CRediT authorship contribution statement Ziying Wang: Writing – original draft, Methodology, Formal analysis, Data curation. Xinwei Zheng: Visualization, Investigation. Qinhui Chen: Supervision. Yunxiang Weng: Supervision. Xun Sun: Writing – review & editing, Supervision, acquisition, Conceptualization. Xianmou Fan: Validation, Software. Guozhen Wang: Validation, Software. Haiqing Liu: Supervision. Yan Fang: Writing – review & editing, Supervision, Conceptualization.

机构署名：

本校为其他机构

院系归属：

食品科学与工程学院

摘要：

Cotton gauze remains a clinically prevalent hemostatic material, yet its effectiveness remains compromised by bleeding. We have deposited cationic quaternized chitosan (QCS) and anionic catechol-functionalized hyaluronic acid (HADA) nanofibers onto cotton gauze to prepare QCS/HADA@gauze. Upon blood contact, oppositely charged nanofibers electrostatically adhere through complementary charge interactions. The interfiber complexation achieves dual hemostatic mechanisms by rapidly establishing a physical barrier while concurrently entrapping circul...

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Oppositely charged polysaccharide nanofibers coated gauze with hemostatic potential

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