γ-Ray irradiation is a common method to sterilize collagen-based materials. However, with more applications of collagen-based materials and more diverse product forms, reports on sensitivity differences of those different forms to irradiation have not been published. In this study, different doses of γ-ray irradiation were used to treat an acidic collagen solution, a PBS collagen solution, a collagen self-assembled gel, and their corresponding freeze-dried sponges to systematically study the effects of irradiation sterilization on the molecul...