The principle of isosterism was employed to design low- or zero-sulfur anti-wear lubricant additives. Thiobenzothiazole compounds and 2-benzothiazole-S-carboxylic acid esters were employed as templates. Sulfur in the thiazole ring or in the branched chain was exchanged with oxygen, CH 2 , or an NH group. Similarly, the template's benzimidazole ring was replaced with a quinazolinone group. Quantitative structure tribo-ability relationship (QSTR) models by back propagation neural network (BPNN) method were used to study correlations between addit...
