Yeast hydrolysate (YH) is rich in amino acids, small peptides, B vitamins, glutathione, and nucleotides, which makes it a possible substitute for spray-dried plasma powder (SDPP). This research was conducted to estimate the application of YH instead of SDPP in creep feed of weaned piglets. The experiment had four treatment groups: (1) basal diet (CON group), (2) CON + 4% YH (YH group), (3) CON + 2% YH + 2% SDPP (SY group), and (4) CON + 4% SDPP (SDPP group). Growth performance, biochemical parameters, immunoglobulin levels, and intestinal tissue morphology were measured. No substantial differe...