Due to repeated microbial infection and an immunosuppressive microenvironment, chronic wound healing can be significantly hindered. The development of multifunctional nanomaterials capable of simultaneous antibacterial and immunomodulatory effects continues to present challenges. Herein, a multifunctional nanocomposite, MXene/Cu(2-x)O, was developed that integrates photothermal therapy (PTT), chemodynamic therapy (CDT), and sonodynamic therapy (SDT), providing tri-modal therapy for synergistic antibacterial and immunomodulatory wound healing. M...