A water extraction and alcohol precipitation method was applied to extract polysaccharides from Codonopsis pilosula (CPP), response surface methodology was used to optimize the extraction conditions and synthesis of C. pilosula polysaccharide iron (CPPI), and the properties of CPPI were evaluated. The optimum extraction conditions for CPP were as follows: liquid-solid ratio of 29.39 mL/g, time of 1.25 h and temperature of 62.84 degrees C. The optimum synthesis conditions for CPPI were pH 8.9, temperature 70.30 degrees C and the ratio of citric acid to CPP1 of 2.95. An HPSEC-MALLS-RID system, U...