The neurotoxicity of Nε-(carboxymethyl)lysine in food processing by a study based on animal and organotypic cell culture

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成果类型：

期刊论文

作者：

Wu, Yang;Li, Yan;Zheng, Liangqing;Wang, Pengcheng;Liu, Yan;...

通讯作者：

Wu, Yongning;Gong, ZhiYong

作者机构：

[Liu, Yan; Wu, Yang; Zheng, Liangqing; Gong, ZhiYong; Wang, Pengcheng] Wuhan Polytech Univ, Minist Educ, Key Lab Deep Proc Major Grain & Oil, Wuhan 430023, Peoples R China.

[Li, Yan] Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Peoples R China.

[Wu, Yongning] Minist Hlth, China Natl Ctr Food Safety Risk Assessment, Key Lab Food Safety Risk Assessment, Beijing 100021, Peoples R China.

[Gong, ZhiYong] Wuhan Polytech Univ, Inst Food Sci & Engn, Wuhan 430023, Peoples R China.

通讯机构：

[Wu, Yongning] M

[Gong, ZhiYong] W

Minist Hlth, China Natl Ctr Food Safety Risk Assessment, Key Lab Food Safety Risk Assessment, Beijing 100021, Peoples R China.

Wuhan Polytech Univ, Inst Food Sci & Engn, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

3D microvascular model;Nepsilon-(Carboxymethyl) lysine;Oxidative stress;p38MAPK-AP-1 signal pathway

期刊：

Ecotoxicology and Environmental Safety

ISSN：

0147-6513

年：

2020

卷：

190

页码：

110077

DOI：

10.1016/j.ecoenv.2019.110077

基金类别：

The National Key Research and Development Program of China 2017YFC1600500.

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

Nepsilon-(carboxymethyl)lysine (CML) is a potentially noxious compound that is causing widespread concern due to its use in various food products. In this study, we investigated CML neurotoxicity via an in vivo experiment with mice, and an in vitro experiment using a 3D microvascular network model (with human brain vascular endothelial cell and human astrocyte) that simulated the blood-brain barrier. We found that CML could induce cell survival status variations, and histopathological changes to the brain. In addition, CML increased levels of oxidative stress, prompted the protein expression o...

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The neurotoxicity of Nε-(carboxymethyl)lysine in food processing by a study based on animal and organotypic cell culture

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