Di-(2-ethylhexyl) phthalate and bisphenol A exposure impairs mouse primordial follicle assembly in vitro

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成果类型：

期刊论文

作者：

Zhang, Teng;Li, Lan;Qin, Xun-Si;Zhou, Yang;Zhang, Xi-Feng;...

通讯作者：

Shen, Wei

作者机构：

[Qin, Xun-Si; Zhou, Yang; Zhang, Teng; Shen, Wei; Li, Lan; Wang, Lin-Qing] Qingdao Agr Univ, Coll Anim Sci & Technol, Lab Germ Cell Biol, Key Lab Anim Reprod & Germplasm Enhancement Univ, Qingdao 266109, Peoples R China.

[Chen, Hong; Li, Lan] Northwest A&F Univ, Coll Anim Sci & Technol, Shaanxi Key Lab Mol Biol Agr, Yangling, Shaanxi, Peoples R China.

[Zhang, Xi-Feng] Wuhan Polytech Univ, Coll Biol & Pharmaceut Engn, Wuhan, Peoples R China.

[De Felici, Massimo] Univ Roma Tor Vergata, Dept Biomed & Prevent, Rome, Italy.

[Qin, Guo-Qing] Inno Tech Nutr Solut, Winnipeg, MB, Canada.

通讯机构：

[Shen, Wei] Q

Qingdao Agr Univ, Coll Anim Sci & Technol, Qingdao 266109, Peoples R China.

语种：

英文

关键词：

di-(2-ethylhexyl) phthalate;bisphenol-A;primordial follicle;Lhx8;DNA methylation

期刊：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

ISSN：

0893-6692

年：

2014

卷：

期：

页码：

343-353

DOI：

10.1002/em.21847

基金类别：

National Basic Research Program of China (973 Program)National Basic Research Program of China [2012CB944401, 2011CB944501]; National Nature Science FoundationNational Natural Science Foundation of China (NSFC) [31201120, 31001010]; Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-12-1026]; Foundation of Distinguished Young ScholarsNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [JQ201109]; Nature Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2011CDB230]; Yantai Hi-Tech Zone Blue Ocean Talent Plan

机构署名：

本校为其他机构

院系归属：

生命科学与技术学院

摘要：

Bisphenol-A (BPA) and diethylhexyl phthalate (DEHP) are estrogenic compounds widely used in commercial plastic products. Previous studies have shown that exposure to such compounds have adverse effects on various aspects of mammalian reproduction including folliculogenesis. The objective of this study was to examine the effects of BPA and DEHP exposure on primordial follicle formation. We found that germ cell nest breakdown and primordial follicle assembly were significantly reduced when newborn mouse ovaries were exposed to 10 or 100 μM BPA a...

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Di-(2-ethylhexyl) phthalate and bisphenol A exposure impairs mouse primordial follicle assembly in vitro

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