Di (2-ethylhexyl) phthalate impairs steroidogenesis in ovarian follicular cells of prepuberal mice

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成果类型：

期刊论文

作者：

Lai, Fang-Nong;Liu, Jing-Cai;Li, Lan;Ma, Jun-Yu;Liu, Xue-Lian;...

通讯作者：

Shen, Wei

作者机构：

[Liu, Jing-Cai; Lai, Fang-Nong] Qingdao Agr Univ, Coll Life Sci, Qingdao 266109, Peoples R China.

[Liu, Jing-Cai; Lai, Fang-Nong; Ma, Jun-Yu; Liu, Xue-Lian; Shen, Wei; Li, Lan; Zhang, Xi-Feng] Qingdao Agr Univ, Inst Reprod Sci, Coll Anim Sci & Technol, Key Lab Anim Reprod & Germplasm Enhancement Univ, Qingdao 266109, Peoples R China.

[Chen, Hong; Li, Lan] Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Peoples R China.

[Liu, Yu-Ping] Qingdao Agr Univ, Hosp Sch, Qingdao 266109, Peoples R China.

[Zhang, Xi-Feng] Wuhan Polytech Univ, Coll Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.

通讯机构：

[Shen, Wei] Q

Qingdao Agr Univ, Inst Reprod Sci, Coll Anim Sci & Technol, Key Lab Anim Reprod & Germplasm Enhancement Univ, Qingdao 266109, Peoples R China.

语种：

英文

关键词：

Di (2-ethylhexyl) phthalate;Pre-puberty mice;Folliculogenesis;Steroidogenesis

期刊：

Archives of Toxicology

ISSN：

0340-5761

年：

2017

卷：

期：

页码：

1279-1292

DOI：

10.1007/s00204-016-1790-z

基金类别：

National Basic Research Program of China (973 Program)National Basic Research Program of China [2012CB944401]; National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31572225, 31471346]

机构署名：

本校为其他机构

院系归属：

生命科学与技术学院

摘要：

Di (2-ethylhexyl) phthalate (DEHP) is a plasticizer which is widely used in the manufacture of plastics. As a common environmental contaminant and recognized endocrine disrupting chemical, DEHP is able to deregulate the functions of a variety of tissues, including the reproductive system both in males and females. In order to investigate the possible effects of DEHP on the first wave of folliculogenesis, occurring in the mouse ovary postnatally, mice were administered 20 or 40 μg/kg DEHP through intraperitoneal injection at days 5, 10 and 15 p...

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Di (2-ethylhexyl) phthalate impairs steroidogenesis in ovarian follicular cells of prepuberal mice

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