[Zeng, Zhisen; Chen, Shuzhen; Ying, Haoran] Xiamen Med Coll, Fujian Prov Key Lab Funct & Clin Translat Med, Xiamen Key Lab Resp Dis, Xiamen 361023, Peoples R China.

[Xu, Jing; Zeng, Zhisen; Bai, Yunhan; Ying, Haoran] Xiarnen Med Coll, Dept Pharm, Xiamen 361023, Peoples R China.

[Ruan, Yaoxin] Xiamen Med Coll, Dept Clin Med, Xiarnen 361023, Peoples R China.

[Chen, Shuzhen] Xiamen Med Coll, Dept Microbiol & Immunol, Xiamen 361023, Peoples R China.

[Chen, SZ] Xiamen Med Coll, Dept Microbiol & Immunol, Fujian Prov Key Lab Funct & Clin Translat Med, Xiamen Key Lab Resp Dis, Xiamen 361023, Peoples R China.

[Chen, SZ ] X

Xiamen Med Coll, Dept Microbiol & Immunol, Fujian Prov Key Lab Funct & Clin Translat Med, Xiamen Key Lab Resp Dis, Xiamen 361023, Peoples R China.

Iron oxide nanoparticles;Size;Inflammatory responses;Oxidative stress;Endoplasmic reticulum stress;IONPs;iron oxide nanoparticles;IL;interleukin;TNF-α;tumor necrosis factor-α;LPS;lipopolysaccharide;RES;reticuloendothelial system;BMMs;bone marrow-derived macrophages;ER;endoplasmic reticulum;PEG;polyethylene glycol;TEM;transmission electron microscopy;DMEM;Dulbecco’s modified Eagle’s medium;FBS;fetal bovine serum;M−CSF;macrophage-colony stimulating factor;Cyto D;Cytochalasin D;DPI;diphenylene iodonium;NAC;N-acetylcysteine;TUDCA;tauroursodeoxycholic acid;SPF;specific-pathogen-free;PBS;phosphate buffered saline;PLF;peritoneal lavage fluid;ELISA;enzyme-linked immunosorbent assay;RNA-seq;RNA-sequencing;FC;fold change;KEGG;Kyoto Encyclopedia of Genes and Genomes;GO;Gene Ontology;SEM;mean ± standard error;WBC;white blood cell;ROS;reactive oxygen species;mtROS;mitochondrial ROS;FDA;food and drug administration;UPR;unfolded protein response;NPs;nanoparticles;ND;not detected