Baicalin and baicalein attenuate hyperuricemic nephropathy via inhibiting PI3K/AKT/NF‐κB signalling pathway

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成果类型：

期刊论文

作者：

Liu, Ziyuan;Xiang, Huilong;Deng, Qin;Fu, Wanting;Li, Yang;...

作者机构：

[Fu, Wanting; Xu, Lingyun; Deng, Qin; Li, Yang; Xiang, Huilong; Yu, Zejun; Liu, Ziyuan] Wuhan Polytech Univ, Sch Life Sci & Technol, Wuhan, Peoples R China.

[Qiu, Yinsheng] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Wuhan, Peoples R China.

[Mei, Zhinan] South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan, Peoples R China.

[Xu, Lingyun] Wuhan Polytech Univ, Sch Life Sci & Technol, Xuefu South Rd 68,Changqing Garden, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

PI3K/AKT/NF-κB pathway;baicalein;baicalin;hyperuricemic nephropathy;monosodium urate

期刊：

Nephrology

ISSN：

1320-5358

年：

2023

卷：

期：

页码：

315-327

DOI：

10.1111/nep.14159

基金类别：

Hubei Provincial Key Laboratory of Animal Nutrition and Feed Science Open Project [201912]; National Natural Science Foundation of China [31572572]

机构署名：

本校为第一机构

院系归属：

动物科学与营养工程学院

摘要：

Aim: Inflammation and apoptosis are main pathological processes that lead to the development of hyperuricemic nephropathy (HN). This study aims to explore whether baicalin (BA) and baicalein (BAI) can relieve the damage through PI3K/AKT/NF-kappa B signal pathway and provide more reliable and precise evidence for the treatment of HN. Methods: HN mice were induced by yeast extract with potassium oxonate (PO), and HK-2 cells were induced by monosodium urate (MSU). Molecular docking, western blot, q-PCR, and other methods were used to explore the changes of various indicators in HN mice and HK-2 c...

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Baicalin and baicalein attenuate hyperuricemic nephropathy via inhibiting PI3K/AKT/NF‐κB signalling pathway

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