Unveiling the molecular interactions between alkyl imidazolium ionic liquids and human serum albumin: Implications for toxicological significance

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成果类型：

期刊论文

作者：

Meng, Shizhen;Yu, Qingqing;Li, Ming;Liu, Xin;Zhao, Xiaole;...

通讯作者：

Liu, X

作者机构：

[Liu, Yan; Meng, Shizhen; Li, Ming; Gong, Zhiyong; Wu, Yongning; Wang, Qiao; Yu, Qingqing; Liu, Xin; Zhao, Xiaole] Wuhan Polytech Univ, Coll Food Sci & Engn, Key Lab Deep Proc Major Grain & Oil, Hubei Key Lab Proc & Transformat Agr Prod,Minist E, Wuhan 430023, Peoples R China.

[Wu, Yongning] Chinese Acad Med Sci, China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, Food Safety Res Unit 2019RU014, Beijing 100021, Peoples R China.

[Wu, Kejia] Jiangnan Univ, Wuxi Sch Med, Wuxi, Jiangsu, Peoples R China.

[Liu, Xin] 68 Xuefu South Rd, Wuhan 430023, Hubei, Peoples R China.

通讯机构：

[Liu, X ] 6

68 Xuefu South Rd, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

关键词：

Human serum albumin;Ionic liquid;Protein binding;Toxicology implication

期刊：

Chemico-Biological Interactions

ISSN：

0009-2797

年：

2023

卷：

386

页码：

110762

DOI：

10.1016/j.cbi.2023.110762

基金类别：

CRediT authorship contribution statement S. Z. M.: Formal analysis, Investigation, Writing - original draft; Q. Q. Y.: Investigation, Performed the experiments, Data curation; M. L.: Software, Validation; X.L.: Supervision, Writing - review & editing, acquisition; Z.X.L. and K. J. W.: Writing - review & editing; Q.W.: Software, Methodology; Y.L.: Visualization, Methodology; Y·N·W.: Supervision, Resources; Z.Y.G.: Resources.

机构署名：

本校为第一机构

院系归属：

食品科学与工程学院

摘要：

Alkyl imidazolium-based ionic liquids (ILs) are promising for diverse industrial applications; however, their growing prevalence has raised concerns regarding human exposure and potential health implications. A critical aspect to be clarified to address the adverse health effects associated with ILs exposure is their binding mode to human serum albumin (HSA). In this study, we delved into the binding interactions between three alkyl imidazolium ILs (1-hexyl-3-methyl-imidazolium (C6[MIM]), 1-ethyl-3-methyl-imidazolium chloride (C8[MIM]) and 1-de...

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Unveiling the molecular interactions between alkyl imidazolium ionic liquids and human serum albumin: Implications for toxicological significance

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