Introduction: Nowadays, attention is growing on the Silicon Photomultipliers (SiPMs) detector for many applications, especially in nuclear medicine. In Positron Emission Tomography (PET) scanner, timing performance of a PET detector plays a significant role in image reconstruction. Methods: This work mainly aims at the processing of timing signal for the purpose of achieving a good timing performance. We applied a timing detector made up of a 3 × 3 × 10mm3 LYSO crystal directly coupled with a large-size SensL SiPM with a sensitive area of 6 ×...