期刊论文

Zong, BB

英文

BMC Veterinary Research

1746-6148

2023

19

1

1-15

10.1186/s12917-023-03808-9

This work was supported by grants from National Natural Science Foundation of China (32102674, 32202814), Hubei Province education department scientific research item (Q20211604), School research projects of Wuhan Polytechnic University (2020Y16), Research Funding (Doctoral research start-up funding) of Wuhan Polytechnic University 2021R2020, and the Open Project of Hubei Key Laboratory of Animal Nutrition and Feed Science (202302, 202314).

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Streptococcus suis serotype 2 (S. suis 2) is an important zoonotic pathogen. Orphan response regulator CovR plays crucial regulative functions in the survivability and pathogenicity of S. suis 2. However, research on the CovR in S. suis 2 is limited. In this study, the regulative functions of CovR in the survivability and pathogenicity were investigated in S. suis 2 isolated from a diseased pig. The deletion of CovR significantly weakened the survivability and pathogenicity of S. suis 2. Compared with the wild-type strain, ΔcovR showed slower ...