Persistent high glucose induced EPB41L4A-AS1 inhibits glucose uptake via GCN5 mediating crotonylation and acetylation of histones and non-histones

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成果类型：

期刊论文

作者：

Liao, Weijie;Xu, Naihan;Zhang, Haowei;Liao, Weifang;Wang, Yanzhi;...

通讯作者：

Xie, Weidong;Zhang, YO

作者机构：

[Xie, Weidong; Liao, Weijie; Wang, Songmao; Xu, Naihan; Jiang, Yuyang; Zhang, Yaou; Zhang, Haowei; Wang, Yanzhi; Zhang, Shikuan] Tsinghua Univ, Tsinghua Shenzhen Int Grad Sch, State Key Lab Chem Oncogen, Shenzhen, Peoples R China.

[Liao, Weijie; Wang, Songmao; Xu, Naihan; Zhang, Haowei; Xie, Weidong; Zhang, Yaou; Wang, Yanzhi; Zhang, Shikuan] Tsinghua Univ, Tsinghua Shenzhen Int Grad Sch, Div Life Sci, Key Lab Hlth Sci & Thchnol, Shenzhen, Peoples R China.

[Liao, Weijie; Wang, Songmao; Zhang, Haowei; Wang, Yanzhi; Zhang, Shikuan] Tsinghua Univ, Sch Life Sci, Beijing, Peoples R China.

[Xu, Naihan; Xie, Weidong; Zhang, Yaou] Tsinghua Univ, Open FIESTA Ctr, Shenzhen, Peoples R China.

[Liao, Weifang] Wuhan Polytech Univ, Coll Life Sci & Technol, Wuhan, Peoples R China.

通讯机构：

[Xie, WD; Zhang, YO ] T

Tsinghua Univ, Tsinghua Shenzhen Int Grad Sch, State Key Lab Chem Oncogen, Shenzhen, Peoples R China.

语种：

英文

关键词：

acetylation;crotonylation;EPB41L4A-AS1;GCN5;T2DM

期刊：

Clinical and Translational Medicine

ISSN：

2001-1326

年：

2022

卷：

期：

DOI：

10.1002/ctm2.699

基金类别：

Shenzhen International Cooperation Research Project [GJHZ20180929162002061]

机构署名：

本校为其他机构

院系归属：

生命科学与技术学院

摘要：

Background Persistent hyperglycemia decreases the sensitivity of insulin-sensitive organs to insulin, owing to which cells fail to take up and utilize glucose, which exacerbates the progression of type 2 diabetes mellitus (T2DM). lncRNAs' abnormal expression is reported to be associated with the progression of diabetes and plays a significant role in glucose metabolism. Herein, we study the detailed mechanism underlying the functions of lncRNA EPB41L4A-AS1in T2DM. Methods Data from GEO datasets were used to analyze the expression of EPB41L4A-AS1 between insulin resistance or type 2 diabetes pa...

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Persistent high glucose induced EPB41L4A-AS1 inhibits glucose uptake via GCN5 mediating crotonylation and acetylation of histones and non-histones

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