To evaluate and compare the safety of four selenium supplements, namely Se-enriched peptides (SeP), yeast selenium (SeY), L-Se-methylselenocysteine (L-SeMc) and sodium selenite (Na(2)SeO(3)), the subchronic toxicity study was designed by 90-day gavage administration in Sprague-Dawley rats. The doses of SeP, SeY, L-SeMc and Na(2)SeO(3) were 0.15, 0.30 and 0.60mg/kg bw/day, with additional dose of 0.45mg/kg L-SeMc (All dose calculated as Se). Symptoms like growling, hair loss and significant weight loss were found at 0.60mg/kg of L-SeMc, but not in other groups. At the dose of 0.60mg/kg, females...
