Preparation of Acetylcholinesterase Inhibitory Peptides from Yellowfin Tuna Pancreas Using Moderate Ultrasound-Assisted Enzymatic Hydrolysis

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成果类型：

期刊论文

作者：

Peng, Pai;Yu, Hui;Xian, Meiting;Qu, Caiye;Guo, Zhiqiang;...

通讯作者：

Xiao, J

作者机构：

[Xian, Meiting; Yu, Hui; Peng, Pai; Qu, Caiye; Xiao, J; Xiao, Juan] Hainan Univ, Key Lab Seafood Proc Haikou, Sch Food Sci & Engn, Hainan Engn Res Ctr Aquat Resources Efficient Util, Hainan 570228, Peoples R China.

[Guo, Zhiqiang] Hainan Univ, Sch Marine Sci & Engn, Haikou 570228, Peoples R China.

[Li, Shuyi; Zhu, Zhenzhou] Wuhan Polytech Univ, Natl R&D Ctr Se rich Agr Prod Proc, Hubei Engn Res Ctr Deep Proc Green, Sch Modern Ind Selenium Sci & Engn,Se Rich Agr Pro, Wuhan 430023, Peoples R China.

通讯机构：

[Xiao, J ] H

Hainan Univ, Key Lab Seafood Proc Haikou, Sch Food Sci & Engn, Hainan Engn Res Ctr Aquat Resources Efficient Util, Hainan 570228, Peoples R China.

语种：

英文

关键词：

AChE inhibitory peptides;Alzheimer’s disease;moderate ultrasound-assisted enzymatic hydrolysis;peptide-enzyme interaction;yellowfin tuna pancreas

期刊：

Marine Drugs

ISSN：

1660-3397

年：

2025

卷：

期：

DOI：

10.3390/md23020075

基金类别：

National Natural Science Foundation of China; [32360578]

机构署名：

本校为其他机构

院系归属：

硒科学与工程现代产业学院

摘要：

Bioactive peptides represent a promising therapeutic approach for Alzheimer's disease (AD) by maintaining cholinergic system homeostasis through the inhibition of acetylcholinesterase (AChE) activity. This study focused on extracting AChE inhibitory peptides from yellowfin tuna pancreas using moderate ultrasound-assisted enzymatic hydrolysis (MUE). Firstly, papain and MUE stood out from five enzymes and four enzymatic hydrolysis methods, respectively, by comparing the degree of hydrolysis and AChE inhibitory activity of different pancreatic pro...

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Preparation of Acetylcholinesterase Inhibitory Peptides from Yellowfin Tuna Pancreas Using Moderate Ultrasound-Assisted Enzymatic Hydrolysis

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