Inhibition of acylglycerol kinase sensitizes DLBCL to venetoclax via upregulation of FOXO1-mediated BCL-2 expression

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ning, Na;Zhang, Si;Wu, Qi;Li, Xun;Kuang, Dong;...

作者机构：

[Li, Xun; Ning, Na; Yang, Xiang-Ping; Xia, Minghui; Wang, Jing; Ba, Hongping; Liu, Huicheng; Weng, Junmei] Huazhong Univ Sci & Technol HUST, Tongji Med Coll, Sch Basic Med, Dept Immunol, Wuhan, Peoples R China.

[Cheng, Xiang; Zhang, Si] HUST, Tongji Med Coll, Union Hosp, Lab Cardiovasc Immunol,Inst Cardiol, Wuhan, Peoples R China.

[Wu, Qi; Wang, Guihua] HUST, Tongji Med Coll, Tongji Hosp, GI Canc Res Inst, Wuhan, Peoples R China.

[Ao, Qilin; Kuang, Dong; Duan, Yaqi; Wang, Guoping] HUST, Tongji Med Coll, Tongji Hosp, Inst Pathol, Wuhan, Peoples R China.

[Ao, Qilin; Kuang, Dong; Duan, Yaqi; Wang, Guoping] HUST, Tongji Med Coll, Sch Basic Med, Dept Pathol, Wuhan, Peoples R China.

语种：

英文

关键词：

DLBCL;Venetoclax;AGK;BCL-2;FOXO1

期刊：

Theranostics

ISSN：

1838-7640

年：

2022

卷：

期：

页码：

5537-5550

DOI：

10.7150/thno.72786

基金类别：

Key Special Project of Ministry of Science and Technology, China [2019YFC1316200]; National Scientific Foundation of China [81974432]

机构署名：

本校为其他机构

摘要：

Background: Despite of the paradigm change on the treatments of acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL) by venetoclax, it has been less successful in the treatment of diffuse large B-cell lymphoma (DLBCL). Here, we explored whether acylglycerol kinase regulates the sensitivity of DLBCLs to venetoclax and its mechanism in both cell lines and preclinical animal models. Methods: The expression of AGK and sensitivity to venetoclax of seven DLBCL cell lines were determined. Upon knockdown and overexpression of AGK by lentivirus in DLBCL cells, the venetoclax-induced apop...

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Inhibition of acylglycerol kinase sensitizes DLBCL to venetoclax via upregulation of FOXO1-mediated BCL-2 expression

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