期刊论文

Thepreparation of fish collagen sustained release material and its ability of loading and release to rhodamine B

Wang, H.

中文

功能材料

1001-9731

2017

48

3

3193-3201

10.3969/j.issn.1001-9731.2017.03.001

国家自然科学基金面上资助项目（21676208） 武汉市科技局应用基础研究资助项目（2016020101010082） 湖北省高等学校优秀中青年科技创新团队计划资助项目（T201208）

本校为第一且通讯机构

以天然鱼源胶原为基质材料,以罗丹明B为模拟负载目标药物,采用不同方法制备负载罗丹明B的胶原缓释材料,以负载率和材料缓释性能作为评价指标,优化了胶原基生物缓释材料的制备工艺条件,探讨了胶原负载罗丹明B的缓释机制。实验结果表明,在直接共混、共混/组装、共混/组装/离心及共混/组装/离心/交联几种方法中,前2种方法制备材料对罗丹明B的负载率较高,但负载材料的缓释效果较差;而后2种方法罗丹明B负载率虽然较低,但展现出较好的缓释能力,其中共混/组装/离心方法的缓释效果最佳。在此基础上,进一步探讨了材料干燥方法和胶原浓度对材料缓释效果的影响。结果表明,在-22,-64,-196℃预冻后冷冻干燥及...

Using fish collagen as load matrix materials, rhodamine B as a simulated load target drug, collagen sustained release material was prepared by different methods. The preparation conditions of collagen biomaterials were optimized according the load rate and release properties of rhodamine B and the release mechanism of collagen loading rhodamine B was discussed. The results showed that in several load methods (direct blend, blend + self-assembly, blend + self-assemble + centrifuge, blend + self-assemble + centrifuge + cross-linking), the first t...