Comparative study of the effects of baicalin and probenecid on microRNA expression profiles in porcine aortic vascular endothelial cells infected by Glaesserella parasuis

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成果类型：

期刊论文

作者：

Guo, Ling;Yang, Yaqiong;Yang, Linrong;Sun, Peiyan;He, Jing;...

通讯作者：

Qiu, YS

作者机构：

[Yang, Yaqiong; Yang, Linrong; Guo, Ling; Sun, Peiyan] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Lab Genet Breeding Reprod & Precis Livestock Farmi, Wuhan 430023, Hubei, Peoples R China.

[Qiu, Yinsheng; Ye, Chun; Zong, Bingbing; He, Jing; Fu, Shulin; Guo, Ling] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

[Qiu, Yinsheng; Ye, Chun; Zong, Bingbing; He, Jing; Fu, Shulin; Guo, Ling] Hubei Collaborat Innovat Ctr Anim Nutr & Feed Safe, Wuhan 430023, Peoples R China.

[Yang, Yaqiong; Yang, Linrong; Guo, Ling; Sun, Peiyan] Hubei Prov Ctr Technol Innovat Domest Anim Breedin, Wuhan 430023, Hubei, Peoples R China.

通讯机构：

[Qiu, YS ] W

Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

Hubei Collaborat Innovat Ctr Anim Nutr & Feed Safe, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

Glaesserella parasuis;MicroRNA;Inflammation;Baicalin;Probenecid

期刊：

BMC Veterinary Research

ISSN：

1746-6148

年：

2025

卷：

期：

页码：

1-16

DOI：

10.1186/s12917-025-04702-2

基金类别：

This work was supported by the National Natural Science Foundation of China (No. 32072917; No. 32273067), and Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University (No. 202301). Hubei Key Laboratory of Animal Nutrition and Feed Science,Wuhan Polytechnic University,202301,National Natural Science Foundation of China,32273067,32072917

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

BACKGROUND: Glaesserella parasuis elicits severe inflammatory responses and vascular damage, thus resulting in high mortality and morbidity in pigs; consequently, early diagnosis and treatment are critical to controlling economic losses. MicroRNAs (miRNAs) have been demonstrated to be involved in vascular endothelial inflammation. Baicalin is an effective Chinese medicinal herb with anti-microbial, anti-inflammatory, and anti-oxidant activity. Probenecid has activity toward multiple mammalian biological processes. Herein, we compared the effects of baicalin and probenecid on the miRNA expressi...

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Comparative study of the effects of baicalin and probenecid on microRNA expression profiles in porcine aortic vascular endothelial cells infected by Glaesserella parasuis

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