L-Arginine improves DNA synthesis in LPS-challenged enterocytes

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成果类型：

期刊论文

作者：

Tan, Bi'e*;Xiao, Hao;Xiong, Xia;Wang, Jing;Li, Guangran;...

通讯作者：

Tan, Bi'e

作者机构：

[Xiao, Hao; Tan, Bi'e; Huang, Bo; Xiong, Xia; Li, Guangran; Wu, Guoyao; Wang, Jing; Yin, Yulong] Chinese Acad Sci, Hunan Prov Engn Res Ctr Healthy Livestock & Poult, Inst Subtrop Agr,Observat & Expt Stn Anim Nutr &, Key Lab Agroecol Proc Subtrop Reg,Minist Agr, Changsha 410125, Hunan, Peoples R China.

[Xiao, Hao; Huang, Bo; Li, Guangran; Wang, Jing] Univ Chinese Acad Sci, Beijing 10008, Peoples R China.

[Hou, Yongqing; Wu, Guoyao] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

[Hou, Yongqing; Wu, Guoyao] Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA.

[Tan, Bi'e] Chinese Acad Sci, Res Ctr Healthy Breeding Livestock & Poultry, Changsha 410125, Hunan, Peoples R China.

通讯机构：

[Tan, Bi'e] C

Chinese Acad Sci, Res Ctr Healthy Breeding Livestock & Poultry, Changsha 410125, Hunan, Peoples R China.

语种：

英文

关键词：

Arginine;Cell Cycle;DNA synthesis;Intestine;Mitochondrial Function

期刊：

FRONTIERS IN BIOSCIENCE-LANDMARK

ISSN：

2768-6701

年：

2015

卷：

期：

页码：

989-1003

DOI：

10.2741/4352

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31330075, 31372326, 31301989, 31272450]; National Key Basic Research Program of ChinaNational Basic Research Program of China [2013CB127301, 2012CB126305]; Texas AAMP;M AgriLife Research [H-8200]

机构署名：

本校为其他机构

院系归属：

动物科学与营养工程学院

摘要：

The neonatal small intestine is susceptible to damage by endotoxin, and this cytotoxicity may involve intracellular generation of reactive oxygen species (ROS), resulting in DNA damage and mitochondrial dysfunction. L-Arginine (Arg) confers a cytoprotective effect on lipopolysaccharide (LPS)-treated enterocytes through activation of the mammalian target of the rapamycin (mTOR) signaling pathway. Arg improves DNA synthesis and mitochondrial bioenergetics, which may also be responsible for beneficial effects of Arg on intestinal mucosal cells. In...

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L-Arginine improves DNA synthesis in LPS-challenged enterocytes

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