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Glycine alleviated diquat-induced hepatic injury via inhibiting ferroptosis in weaned piglets

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成果类型:
期刊论文
作者:
Hua, Hongwei;Xu, Xiao;Tian, Wei;Li, Pei;Zhu, Huiling;...
通讯作者:
Xiao, K.
作者机构:
[Hua, Hongwei; Li, Pei; Xu, Xiao; Liu, Yulan; Xiao, Kan; Tian, Wei; Zhu, Huiling] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.
[Tian, Wei; Wang, Wenjun] South Cent Univ Nationalities, Coll Life Sci, Wuhan 430074, Peoples R China.
通讯机构:
[Xiao, K.] H
Hubei Key Laboratory of Animal Nutrition and Feed Science, China
语种:
英文
关键词:
Ferroptosis;Glycine;Liver;Oxidative Stress;Weaned Piglets
期刊:
ANIMAL BIOSCIENCE
ISSN:
2765-0189
年:
2022
卷:
35
期:
6
页码:
938-947
基金类别:
This study was supported by the Projects of Innovative Research Groups of the Natural Science Foundation of Hubei Province (No. 2019CFA015), and the National Natural Science Foundation of China (No. 31802076, and No. 31772615), the Open Project of Hubei Key Laboratory of Animal Nutrition and Feed Science (No. 201802).
机构署名:
本校为第一机构
院系归属:
动物科学与营养工程学院
摘要:
Objective: The beneficial effects of glycine were tested in piglets with diquat-induced hepatic injury. Methods: Thirty-two piglets were assigned by a 2×2 factorial experimental design including glycine supplementation and diquat challenge. After 3 weeks of feeding with a basic diet or a 1% glycine supplemented diet, piglets were challenged with diquat or saline. After 1 week later, the piglets were slaughtered and samples were collected. Results: Our results indicated that glycine alleviated diquat induced morphological hepatic injury, decrea...

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