Potential components and action mechanism of Tongzhi Surunjiang Pills against acute gouty arthritis: UPLC-MS/MS, network pharmacology, molecular docking, and transcriptomic analysis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Fu, Wanting;Ye, Aoqi;Yang, Huimin;Hou, Xia;Wang, Zhongjing;...

通讯作者：

Xu, LY

作者机构：

[Fu, Wanting; Hou, Xia; Yu, Zejun; Yang, Huimin; Li, Xindi; Ye, Aoqi; Yu, Xiang; Xu, Lingyun; Li, Yang] Wuhan Polytech Univ, Sch Life Sci & Technol, Xuefu South Rd 68, Wuhan 430023, Peoples R China.

[Wang, Zhongjing] Cent Hosp Wuhan, Dept Endocrinol, Wuhan 430014, Peoples R China.

[Hu, Zhun] Wuhan Tongji Zhongwei Pharmaceut Co Ltd, Res & Dev Ctr, Wuhan 430100, Peoples R China.

[Qiu, Yinsheng] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Wuhan 430023, Peoples R China.

[Mei, Zhinan] Huazhong Agr Univ, Coll Plant Sci & Technol, Wuhan 430070, Peoples R China.

通讯机构：

[Xu, LY ] W

Wuhan Polytech Univ, Sch Life Sci & Technol, Xuefu South Rd 68, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

Anti-inflammatory;Gouty arthritis;Tongzhi Surunjing pills;UPLC-MS

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2026

卷：

354

页码：

120516

DOI：

10.1016/j.jep.2025.120516

基金类别：

Hubei Provincial Administration of Traditional Chinese Medicine Research Project [ZY2023M075]; Wuhan Polytechnic University Professional Degree Graduate Course Case Library Construction Project (School Graduate [2023]) [7]; Wuhan Polytechnic University 2023 Annual Graduate Education and Teaching Achievements Cultivation Project (School Graduate [2023]) [4]

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Ethnopharmacological relevance Gouty arthritis (GA) is a disease caused by the malfunction of purine and/or uric acid metabolism. Tongzhi Surunjing Pills (TZSRJP), a traditional Chinese medicine formula derived from the ancient Uyghur book “Karzhibadin Kadeer”, is used clinically to treat GA, which still needs more research in its complex regulatory mechanisms. Gouty arthritis (GA) is a disease caused by the malfunction of purine and/or uric acid metabolism. Tongzhi Surunjing Pills (TZSRJP), a traditional Chinese medicine formula derived from...

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Potential components and action mechanism of Tongzhi Surunjiang Pills against acute gouty arthritis: UPLC-MS/MS, network pharmacology, molecular docking, and transcriptomic analysis

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