Design, synthesis, and biological evaluation of new ALDH2 activators

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Hu, Jian;Tian, Wei;Zhou, Ruolan;Zhang, Yuefan;Lv, Jiaguo;...

通讯作者：

Xin Chen<&wdkj&>Xianhua Pan<&wdkj&>Canhui Zheng

作者机构：

[Hu, Jian; Pan, Xianhua] Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 201418, Peoples R China.

[Hu, Jian; Tian, Wei; Zhou, Ruolan; Zhang, Yuefan; Lv, Jiaguo; Zhu, Ju; Zheng, Canhui] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China.

[Tian, Wei] Wuhan Gen Hosp Guangzhou Command, Wuhan 430070, Hubei, Peoples R China.

[Zhou, Ruolan; Chen, Xin] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Hubei, Peoples R China.

通讯机构：

[Xin Chen; Xianhua Pan; Canhui Zheng] S

School of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, China<&wdkj&>School of Pharmacy, Second Military Medical University, Shanghai 200433, China<&wdkj&>School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, China

语种：

英文

关键词：

Mitochondrial aldehyde dehydrogenase 2;Activators;Synthesis;Biological evaluation

期刊：

Journal of Saudi Chemical Society

ISSN：

1319-6103

年：

2019

卷：

期：

页码：

255-262

DOI：

10.1016/j.jscs.2018.07.001

基金类别：

Shanghai Rising-Star Program [16QA1404800]

机构署名：

本校为其他机构

院系归属：

生命科学与技术学院

摘要：

Mitochondrial aldehyde dehydrogenase 2(ALDH2) is an important enzyme response for the metabolism or detoxification of toxic aldehydes, in particular acetaldehyde and 4-hydroxynonenal (4-HNE), which were important risk factors for acute alcoholism and stroke respectively. A special variant ALDH2*2 with reduced enzymatic activity was carried by a high percentage of East Asians, especially Han Chinese, and that could increase the risk of these diseases further. Therefore, ALDH2 activators had important potential clinical values. N-benzylbenzamide compounds represented by Alda-1 were the only ALDH...

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Design, synthesis, and biological evaluation of new ALDH2 activators

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