Hot isostatic pressing (HIP) has an important influence on the pore closure behavior and the microstructure evolution around pores in Ti6Al4V alloy castings. Therefore, experiments including the preparation of HIP samples and interrupted HIP experiments, and finite element numerical simulations were used to analyze the evolution of pore volume, distribution of stress and strain in Ti6Al4V alloy during HIP. After the mechanical closure of pores, molecular dynamics simulations were used to study the effect of temperatures and numbers of grains on the micropore closure. Finally, SEM/EBSD methods ...