Has-miR-199a-3p/RELA/SCD inhibits immune checkpoints in AMD and promotes macrophage-mediated inflammation and pathological angiogenesis through lipid metabolism pathway: A computational analysis

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成果类型：

期刊论文

作者：

Jiang, Jiang;Wang, Shu;Li, Yun;Wang, Yi;Liao, Rongfeng

通讯作者：

Liao, RF

作者机构：

[Jiang, Jiang; Liao, Rongfeng] Anhui Med Univ, Dept Urol, Affiliated Hosp 1, Hefei, Anhui, Peoples R China.

[Jiang, Jiang] Anhui Med Univ, Dept Ophthalmol, Affiliated Hosp 3, Hefei, Anhui, Peoples R China.

[Wang, Shu] Anhui Med Univ, Dept Geriatr, Affiliated Hosp 3, Hefei, Anhui, Peoples R China.

[Li, Yun] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan, Peoples R China.

[Li, Yun] Kindstar Global Precis Med Inst, Wuhan, Peoples R China.

通讯机构：

[Liao, RF ] A

Anhui Med Univ, Dept Urol, Affiliated Hosp 1, Hefei, Anhui, Peoples R China.

语种：

英文

期刊：

PLOS ONE

ISSN：

1932-6203

年：

2024

卷：

期：

页码：

e0297849

DOI：

10.1371/journal.pone.0297849

机构署名：

本校为其他机构

院系归属：

生命科学与技术学院

摘要：

More and more evidence shows that abnormal lipid metabolism leads to immune system dysfunction in AMD and promotes the occurrence of AMD by changing the homeostasis of ocular inflammation. However, the molecular mechanism underlying the effect of lipid metabolism on the phenotype and function of macrophages is still unclear, and the mechanism of association between AMD and cancer and COVID-19 has not been reported. The purpose of this study is to explore the interaction between lipid metabolism related genes, ferroptosis related genes and immunity in AMD, find out the key genes that affect the...

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Has-miR-199a-3p/RELA/SCD inhibits immune checkpoints in AMD and promotes macrophage-mediated inflammation and pathological angiogenesis through lipid metabolism pathway: A computational analysis

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