期刊论文

Yi, P.;Zhao, X.

英文

Cells

2073-4409

2022

11

20

3199-

10.3390/cells11203199

X.Z.: methodology and supervision. Q.W.: conceptualization and funding acquisition. H.C. (Hongbiao Chen): responsible for the research of the entire experiment, including the main design of the experimental protocol, the operation of the entire animal experiment (including the extraction and detection of samples), and the metabolomics analysis and visualization of the entire experimental data, follow-up paper writing, review, revision, and submission. Y.L.: extraction of fish phospholipids and detection of phospholipid nutrients; Partial animal testing; Sample collection, metabolomics sample testing and partial data analysis; Design work for part of the study; Submission and revision work. P.Y.: participated in the design of research, review and revision of articles. H.C. (Hui Cao): investigation, formal analysis, resources and validation. All authors have read and agreed to the published version of the manuscript. This work was supported by the Key Research and Development Program of the Ministry of Science and Technology (2018YFD0901103).

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The number of metabolic syndromes (MetS) is increasing, and a fish phospholipid diet can reduce the risk of MetS. In this study, the changes in lipid metabolism of colon contents were analyzed by extensive lipidomics in mice with metabolic syndrome by fish phospholipid diet, and mice were randomly divided into experimental groups with different diet types by establishing a MetS model. After 14 weeks, the mice were sacrificed and the serum and colon contents were collected. Ultra-high liquid phase tandem mass spectrometry was used for broadly targeted lipidomic analysis, and the qualitative and...