A hydrogel composite verteporfin‐carboxymethyl chitosan‐oxidized sodium alginate (VP‐CMCS‐OSA) of CMCS and OSA, with loading anti‐fibrotic drug VP, is developed based on two‐step chemical reactions. The VP‐CMCS‐OSA hydrogel demonstrates the properties of high tissue adhesion, strong self‐healing, and tensile ability, and prompts full‐thickness skin wound healing due to the synergistic effects of hydrogels and verteporfin administration. Abstract Full‐thickness skin defect has always been a major challenge in clinics due to fibrous hy...
