The modulation of the excitability of primary sensory neurons by Ca2+-CaM-CaMKII pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liang, Renjie;Liu, Xianli;Wei, Limin;Wang, Wei;Zheng, Ping;...

通讯作者：

Liu, Lieju

作者机构：

[Liu, Lieju; Cao, Xuehong] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan, Hubei, Peoples R China.

[Cao, Xuehong] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.

[Liu, Lieju; Cao, Xuehong; Zhao, Yilin; Yan, Xisheng; Zheng, Ping] Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan 430074, Hubei, Peoples R China.

[Wang, Wei] Hubei Women & Childrens Hosp, Dept Pediat Neurol Rehabil, Wuhan, Hubei, Peoples R China.

通讯机构：

[Liu, Lieju] W

Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan, Hubei, Peoples R China.

语种：

英文

关键词：

Ca2+/calmodulin-dependent protein kinase II;Neuron;Voltage-gated sodium channels;Voltage-gated potassium channels;Nociception

期刊：

Neurological Sciences

ISSN：

1590-1874

年：

2012

卷：

期：

页码：

1083-1093

DOI：

10.1007/s10072-011-0907-7

基金类别：

National Institutes of Health (NIH)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [GM-63577]; National Natural Science Foundation (NNSF)National Natural Science Foundation of China (NSFC) [30571537, 30271500]; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [R01GM063577, R01GM063577, R01GM063577, R01GM063577, R01GM063577] Funding Source: NIH RePORTER

机构署名：

本校为第一且通讯机构

院系归属：

生命科学与技术学院

摘要：

Ca 2+ -calmodulin (CaM) dependent protein kinase II (CaMKII) is an important intracellular signal transduction pathway. CaMKII is rich in the primary sensory neurons and specifically presents in the small- and mediumsized neurons. It remains unclear about the modulation on the excitability of primary sensory neurons by Ca 2+ -CaM- CaMKII pathway. By current clamp recording, we found that the excitability of capsaicin-sensitive small and medium trigeminal ganglion (TG) neurons was significantly reduced by a CaM specific antagonist (W-7) and a Ca...

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The modulation of the excitability of primary sensory neurons by Ca2+-CaM-CaMKII pathway

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