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The modulation of the excitability of primary sensory neurons by Ca 2+-CaM-CaMKII pathway

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成果类型:
期刊论文
作者:
Liang, Renjie;Liu, Xianli;Wei, Limin;Wang, Wei;Zheng, Ping;...
通讯作者:
Liu, Lieju
作者机构:
[Liu, Lieju; Cao, Xuehong] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan, Hubei, Peoples R China.
[Cao, Xuehong] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Liu, Lieju; Cao, Xuehong; Zhao, Yilin; Yan, Xisheng; Zheng, Ping] Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan 430074, Hubei, Peoples R China.
[Wang, Wei] Hubei Women & Childrens Hosp, Dept Pediat Neurol Rehabil, Wuhan, Hubei, Peoples R China.
通讯机构:
[Liu, Lieju] W
Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan, Hubei, Peoples R China.
语种:
英文
关键词:
aip;analgesic agent;calcium calmodulin dependent protein kinase II;capsaicin;n (6 aminohexyl) 5 chloro 1 naphthalenesulfonamide;n [2 [[n [3 (4 chlorophenyl) 2 propenyl] n methylamino]methyl]phenyl] n (2 hydroxyethyl) 4 methoxybenzenesulfonamide;protein kinase inhibitor;unclassified drug;voltage gated potassium channel;voltage gated sodium channel;animal cell;article;controlled study;drug sensitivity;enzyme inhibition;enzyme localization;intracellular signaling;male;nerve cell excitability;nerve potential;neuromodulation;nociception;nonhuman;patch clamp;potassium current;rat;sensory nerve cell;signal transduction;sodium current;trigeminus ganglion;voltage clamp;Animals;Calcium-Calmodulin-Dependent Protein Kinase Type 2;Calmodulin;Male;Nociception;Patch-Clamp Techniques;Rats;Rats, Sprague-Dawley;Sensory Receptor Cells;Signal Transduction;Trigeminal Ganglion
期刊:
Neurological Sciences
ISSN:
1590-1874
年:
2012
卷:
33
期:
5
页码:
1083-1093
基金类别:
This work was supported by National Institutes of Health (NIH) grant GM-63577, National Natural Science Foundation (NNSF) grant 30571537 and NNSF grant 30271500.
机构署名:
本校为第一且通讯机构
院系归属:
生命科学与技术学院
摘要:
Ca2+-calmodulin (CaM) dependent protein kinase II (CaMKII) is an important intracellular signal transduction pathway. CaMKII is rich in the primary sensory neurons and specifically presents in the small- and mediumsized neurons. It remains unclear about the modulation on the excitability of primary sensory neurons by Ca2+-CaM- CaMKII pathway. By current clamp recording, we found that the excitability of capsaicin-sensitive small and medium trigeminal ganglion (TG) neurons was significantly reduced by a CaM specific antagonist (W-7) and a CaMKII...

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