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Modulation of the Self-Assembly of Collagen by Phytic Acid: An In Vitro Study

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成果类型:
期刊论文
作者:
Tu, Xiao;Chen, Xincheng;Peng, Ying;Nan, Jie;Wei, Benmei;...
通讯作者:
Zhang, Juntao;Wang, Haibo
作者机构:
[Xu, Yuling; Xu, Chengzhi; Zhang, Juntao; Wang, Haibo; Chen, Xincheng; Peng, Ying; Xie, Dong; Wei, Benmei; Tu, Xiao; He, Lang; Nan, Jie] Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan 430023, Hubei, Peoples R China.
通讯机构:
[Zhang, JT; Wang, HB] W
Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan 430023, Hubei, Peoples R China.
语种:
英文
关键词:
Amination;Collagen;Differential scanning calorimetry;Enzyme kinetics;High resolution transmission electron microscopy;Hydrogels;Scanning electron microscopy;Structure (composition);Thermodynamic stability;Transmission electron microscopy;Assembly kinetics;Collagen fibrils;D-periodicity;Phosphate group;Phytic acids;property;Self-assembly behaviors;Structures and properties;Self assembly
期刊:
Macromolecular Research
ISSN:
1598-5032
年:
2018
卷:
26
期:
13
页码:
1233-1240
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21676208, 21706201, 21376183]; Science and Technology Project of Wuhan city, China [2016020101010082]; Wuhan Morning Light Plan of Youth Science and Technology [2017050304010326]; Hubei Provincial Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [2018CFA030, 2017CFB507]
机构署名:
本校为第一且通讯机构
院系归属:
化学与环境工程学院
摘要:
Phytic acid, containing a myoinositol ring coupled with six phosphate groups, can react with the amino groups of collagen to regulate their self-assembly behavior. The aim of this research is to evaluate the effects of phytic acid on the selfassembly behavior of collagen, the structures and properties of the resulting fibrils and hydrogels. Turbidity and chloramine T assay suggested that phytic acid could improve the self-assembly kinetics and degree of collagen, and the optimal ratio of phytic acid/collagen was 1/1 (w/w). Scanning electron mic...

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