期刊论文

中文

中国医院药学杂志

1001-5213

2008

28

17

1456-1458

10.3321/j.issn:1001-5213.2008.17.009

湖北省“十五”重大科技攻关项目（编号:2004AA304A）；

本校为第一机构

目的：研究人工栽培玄参中色素提取物的抗炎镇痛作用。方法：采用热板法、冰醋酸刺激致痛法测定小鼠痛阈；利用二甲苯造小鼠耳廓炎症模型，测定小鼠耳片质量；采用腹腔染料渗出法，测定小鼠腹腔毛细血管通透性。结果：玄参色素提取物能提高热板致病小鼠的痛阁值及减少冰醋酸刺激致痛小鼠的扭体次数；对二甲苯致小鼠耳廓肿胀、冰醋酸致腹腔毛细血管通透性增高均有明显的抑制作用。结论：玄参色素提取物有抗炎镇痛的活性。

OBJECTIVE To study the anti-inflammatory and analgesic effect of pigments from Scrophularia ningpoensis Hemsl. METHODS Hot plate law, acetic acid glacial stimulation-induced pain law were adopted to observe the analgesic effect; the xylene induced mouse auricle inflammation model and dye peritoneal exudation model were used to observe the anti-inflammatory effect of pigments from Scrophularia ningpoensis. RESULTS Pigments from Scrophularia ningpoensis Hernsl gavaged in mice significantly prolonged time of pain threshold and significantly reduced writhing times. In addition, the auricle inflamm...