期刊论文

Study on anti-diarrhea effects of Rhubarb charcoal

中文

中国医院药学杂志

1001-5213

2015

35

11

996-1000

10.13286/j.cnki.chinhosppharmacyj.2015.11.07

湖北省高等学校省级科研项目

本校为第一机构

目的: 探讨大黄炭对腹泻模型小鼠的抗腹泻作用。方法: 利用番泻苷A 诱导建立致KM 小鼠腹泻模型,给予大黄炭4g·kg~(-1)·d~(-1)灌胃处理7 d,采用炭墨推进实验方法,研究大黄炭对肠道蠕动功能的影响; 通过截取小鼠大、小肠称取干、湿重,研究大黄炭对不同肠段水分吸收的作用; 利用选择性培养基对小鼠粪便菌群进行培养,研究大黄炭对肠道菌群的作用; 运用显微镜观察大黄炭对腹泻模型鼠肠黏膜组织病理变化的影响。结果: 腹泻小鼠给予大黄炭干预后,腹泻指数0. 43 ± 0. 16较腹泻组1. 43 ± 0. 23明显减少(P < 0. 05); 小、大肠的水分含量也出现明显的降低(P < 0. 01); 肠道蠕动显著减缓(P < 0. 05); 肠...

OBJECTIVE To investigate anti-diarrhea effects of charred rheum charcoal on model mouse suffering from diarrhea. METHODS Diarrhea model of KM mouse was induced by sennoside A. Charred rheum charcoal was administered at 4 g·kg~(-1)·d~(-1) via intragastric infusion for 7 d. Carbon power propulsion experiment was adopted to study on effects of charred rheum charcoal on intestinal peristalsis. Small and large intestines of mice were excised and corresponding dry and wet weights were measured respectively, to investigate effects of charred rheum c...