Comparative proteomic analysis of cerebral cortex revealed neuroprotective mechanism of esculentoside A on Alzheimer\'s disease - 成果

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Comparative proteomic analysis of cerebral cortex revealed neuroprotective mechanism of esculentoside A on Alzheimer's disease

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成果类型：

期刊论文

作者：

He, Zhijun;Zhang, Huajie;Li, Xiaoqian;Shen, Liming;Li, Nan;...

通讯作者：

Cheng, SY;Liu, Q

作者机构：

[Li, Xiaoqian; Zhang, Huajie; He, Zhijun; Li, Nan; Liu, Qiong; Shen, Liming] Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen Key Lab Marine Biotechnol & Ecol, Shenzhen 518055, Guangdong, Peoples R China.

[Cheng, Shuiyuan; Cheng, SY; He, Zhijun] Wuhan Polytech Univ, Natl R&D Ctr Serich Agr Prod Proc, Sch Modern Ind Selenium Sci & Engn, Hubei Engn Res Ctr Deep Proc Green Serich Agr Prod, Wuhan 430023, Peoples R China.

[Li, Nan; Liu, Qiong] Shenzhen Hong Kong Inst Brain Sci Shenzhen Fundame, Shenzhen 518055, Peoples R China.

[Liu, Qiong] Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen 518055, Peoples R China.

通讯机构：

[Liu, Q ] S

[Cheng, SY ] W

Wuhan Polytech Univ, Natl R&D Ctr Serich Agr Prod Proc, Sch Modern Ind Selenium Sci & Engn, Hubei Engn Res Ctr Deep Proc Green Serich Agr Prod, Wuhan 430023, Peoples R China.

Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen 518055, Peoples R China.

语种：

英文

关键词：

Alzheimer's disease (AD);Cerebral cortex;Esculentoside A (EsA);Proteomics

期刊：

European Journal of Pharmacology

ISSN：

0014-2999

年：

2024

卷：

964

页码：

176226

DOI：

10.1016/j.ejphar.2023.176226

基金类别：

information This study was financially supported by the Shenzhen Science and Technology Innovation Commission (JCYJ20200109110001818) and the Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions (2023SHIBS0003). This work was also jointly supported by the National Key Research and Development Program of China (2018YFE0118900).

机构署名：

本校为通讯机构

院系归属：

硒科学与工程现代产业学院

摘要：

Esculentoside A (EsA), isolated from phytolacca esculenta, is a saponin showing neuroprotective effect in the mouse models of Alzheimer's disease (AD). To investigate its action target and underlying mechanism, this study used the proteomics technique of isobaric tags for relative and absolute quantification (iTRAQ) to analyze the differentially expressed proteins (DEPs) in the cerebral cortex of EsA-treated and untreated triple-transgenic 3×Tg-AD model mice. Proteomic comparison revealed 250, 436, and 903 DEPs in three group pairs, i.e. AD/Wi...

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Comparative proteomic analysis of cerebral cortex revealed neuroprotective mechanism of esculentoside A on Alzheimer's disease

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