期刊论文

中文

中国免疫学杂志

1000-484X

2014

30

1

105-109

10.3969/j.issn.1000-484X.2014.01.021

湖北省教育厅科研计划项目（Q20121808）资助；

本校为第一机构

目的:甄别、测量与评估大鼠肾移植继发自身免疫反应的致病性。方法:使用保留受体自体肾的F344-Lewis大鼠肾移植模型（AI组）、Lewis大鼠自体肾单纯缺血再灌注模型（IR组）、同系移植肾病大鼠脾细胞过继并Lewis大鼠自体肾缺血再灌注模型（AR组）,以Lewis大鼠自体肾移植作为对照（Syn组）。术后第10周检测大鼠受体血清vimentin抗体水平,动态监测蛋白尿水平,术后第40周检测自体肾肾小球硬化指数、肾脏IgG沉积。结果:术后第10周AI组和AR组血清vimentin抗体水平比Syn组显著升高（0.312±0.036,0.310±0.017 vs.0.061±0.012）,IR组则无明显改变,显示AI组和AR组有自身免疫反应发生。AI及IR组蛋白尿水平...

Objective：To distinguish, measure and evaluate the pathogenicity of subsequent autoimmunity following renal transplantation in rats. Methods： Lewis rats of receiving F344 rat renal transplant as well as reserving the autologous kidney （AI groups） , the autologons kidney following isehemia reperfusion （IR group ） and the autologous kidney following isehemia reperfusion which the host be transferred splenocytes from syngenic rat undergoing chronic allograft nephropathy （AR group） were investigated. Rats of syngenic renal transplants acted...