期刊论文

Wu, Guoyao

英文

PLOS ONE

1932-6203

2014

9

6

e97815

10.1371/journal.pone.0097815

National Basic Research Program of ChinaNational Basic Research Program of China [2013CB12730]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31001014, 530901040, 31110103909, 30928018, 31101729]; Dr. Li Jieshou (Academician of CAS) Research Fund for Intestinal Barrier [LJS_201006]; Research Foundation [SKLF-TS-201108, SKLF-TS-200817]; Open Project Program of State Key Laboratory of Food Science and Technology, Nanchang University [SKLF-KF-201005, SKLF-KF-201216]; Texas A&M AgriLife Research [H-8200]; Chinese Academy of Sciences Visiting Professorship for Senior International Scientists Grant [2011T2S15]; National Cancer InstituteUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [R25T-CA090301]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [R25CA090301, R25CA090301, R25CA090301, R25CA090301, R25CA090301, R25CA090301, R25CA090301, R25CA090301, R25CA090301, R25CA090301, R25CA090301, R25CA090301, R25CA090301, R25CA090301, R25CA090301] Funding Source: NIH RePORTER

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Chlorogenic acid, a natural phenolic acid present in fruits and plants, provides beneficial effects for human health. The objectives of this study were to investigate whether chlorogenic acid (CHA) could improve the intestinal barrier integrity for weaned rats with lipopolysaccharide (LPS) challenge. Thirty-two weaned male Sprague Dawley rats (21 +/- 1 d of age; 62.26 +/- 2.73 g) were selected and randomly allotted to four treatments, including weaned rat control, LPS-challenged and chlorogenic acid (CHA) supplemented group (orally 20 mg/kg and 50 mg/kg body). Dietary supplementation with CHA ...