Purpose: To improve the solubility and stability of arbutin and to expand its application by preparing its inclusion complex with hydroxypropyl-β- cyclodextrin (HP-β-CD).Methods: An inclusion complex made of arbutin and hydroxypropyl-β-cyclodextrin (HP-β-CD) was prepared by freeze-drying method. Various analytical techniques, including ultraviolet-visible spectroscopy (UV), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), x-ray diffractometry (XRD) and thermo-gravimetric/differential scanning calorimetry ...
