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Structural characterization, acute toxicity assessment and protective effects of selenylated apple pectin on dextran sulfate sodium-induced ulcerative colitis

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成果类型:
期刊论文
作者:
Tao, Wen;An, Xiaoyu;Guo, Ziqi;Yang, Ning;Wu, Muci;...
通讯作者:
Zhang, Rui(ruizhangwhpu@126.com);He, Jingren(ruizhangwhpu@126.com)
作者机构:
[An, Xiaoyu; Guo, Ziqi; Zhang, Rui; Wu, Muci; Tao, Wen; He, Jingren] Wuhan Polytech Univ, Natl R&D Ctr Se Rich Agr Prod Proc, Hubei Engn Res Ctr Deep Proc Green Se Rich Agr Pr, Sch Modern Ind Selenium Sci & Engn, 36 Huanhu Middle Rd, Wuhan 430023, Peoples R China.
[Zhang, Rui; He, Jingren; Yang, Ning] Wuhan Polytech Univ, Key Lab Deep Proc Major Grain & Oil, Hubei Key Lab Proc & Transformat Agr Prod, 36 Huanhu Middle Rd, Wuhan 430023, Peoples R China.
[Oliveira, Helder] Univ Porto, Fac Ciencias, Dept Quim & Bioquim, REQUIMTE, Rua Campo Alegre S-N, P-4169007 Porto, Portugal.
通讯机构:
[Rui Zhang; Jingren He] N
National R&D Center for Se-rich Agricultural Products Processing, Hubei Engineering Research Center for Deep Processing of Green Se-rich Agricultural Products, School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, No. 36 Huanhu Middle Road, Jinyinhu District, Wuhan 430023, P. R. China<&wdkj&>Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education, Hubei Key Laboratory for Processing and Transformation of Agricultural Products, Wuhan Polytechnic University, No. 36 Huanhu Middle Road, Jinyinhu District, Wuhan 430023, P. R. China
语种:
英文
期刊:
FOOD & FUNCTION
ISSN:
2042-6496
年:
2022
卷:
13
期:
13
页码:
7320-7332
基金类别:
All authors are thankful for the financial support from the fund of “Chutian Scholar Plan”, the Technical Innovation Special Major Project (2019ABA113), and the Key Research and Development Program Project (2020BBA043) by Hubei Province. This research was also funded by the Hubei Key Laboratory for Processing and Transformation of Agricultural Products (Wuhan Polytechnic University, 2020HBSQGDKFB11).
机构署名:
本校为第一机构
院系归属:
食品科学与工程学院
硒科学与工程现代产业学院
摘要:
This study was aimed at investigating the structural characterization, acute toxicity and protective effect of selenylated apple pectin on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice. Selenylated apple pectin was characterized by ion chromatography, NMR and SEC-RI-MALLS. The acute toxicity and protective effect of selenylated apple pectin against UC were investigated by gavage administration in mice. The organ state and coefficients, inflammatory cytokine (IL-6, IL-10 and TNF-α) contents in serum, GSH-Px activity and M...

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