The poor water solubility of apigenin limits its application feasibility in food and medicine. To address this issue, this study successfully prepared apigenin-loaded zein composite nanoparticles using the pH-driven self-assembly method. The nanoparticles were stabilized by hydrophilic whey protein isolate and carboxymethyl cellulose. The composite nanoparticles exhibited high potential, small size, and uniform particle size distribution. Circular dichroism and fluorescence spectroscopy results revealed that the nanoparticles showed conformatio...
